Every Blood Sample Is A Life

Proprietary Probe Technology Helps Reduce Sample Cross-Contamination

We are often asked about the importance of our proprietary probe technologies that help to minimize cross-contamination from one test sample to the next. Our exclusive probe polishing process reduces ID roughness by a factor of 2 to 4 and improves wash characteristics enabling earlier and more accurate diagnostic testing of serious diseases.

Perhaps a short, memorable example serves best, especially when describing the importance of reducing sample cross-contamination that could potentially lead to an incorrect diagnosis.

Imagine an e-mail intended for your boss is sent to a customer instead. That’s not the desired outcome and is embarrassing to all involved. Hopefully, it is little more than an inconvenience. Similar to the content within the misaddressed e-mail, a patient’s details, their blood sample and their diagnostic blood test must be cleanly handled to achieve an accurate outcome. Thus, preventing diagnostic errors, whether human- or instrument-induced, now becomes a more urgent priority, especially when they could affect your test sample.

The bottom line: Every sample is a life. Treating each and every diagnostic blood sample in that way humanizes each test result. This also helps to better illustrate the importance of limiting cross-contamination through innovative and repeatable proprietary probe technology within diagnostic instruments to improve both sample test accuracy and deliver consistent test outcomes.

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Reduce The Internal Surface Roughness Of A Probe With DP3®

Newly marketed diagnostic instruments and their assays are becoming more and more sensitive. This greater sensitivity is likely to require more stringent control of carryover from one sample being tested to the next. Thus, a probe’s internal diameter (ID) surface finish now plays a greater role in the ability of the instrument to accurately analyze and diagnose the presence of infections and disease.

It’s these small, hard-to-reach rough areas within a probe’s ID that invite carryover and increasingly become problematic for OEM design teams as previous probe manufacturing technologies are just not up to snuff.

So, where does one turn for an alternative?

Coatings are one approach tried by many instrument designers. But how can you tell if a coating starts to flake off inside the probe?

Enter DP3®
DP3 is Diba’s precision technology that polishes and smooths a probe’s internal surface and reduces surface roughness by up to 75%. This proprietary process improves wash characteristics and creates an extremely durable surface that can enhance the performance of an existing probe design, and unlike coatings, will not flake off over time.

When coupled with Diba’s proprietary probe draw down process to reduce tip ID while maintaining a smooth inner surface, DP3 enables precise dispense and aspirate functions for the most demanding new diagnostic assays.

Diba’s application engineers work closely with our customers’ OEM engineering teams to customize probe design according to the application needs of each instrument. Our customers have verified that this attention to detail can become the deciding difference for sensitive assays, where any minute amount of carryover can become a serious problem.

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When All Else Fails, Listen To Your Customer

At Diba, we strive to be close enough to customers that they will share their fluid handling challenges with us. Here is one such case below.

The Need:
The R&D Engineers at a Diba customer in the business of manufacturing diagnostic test kits for clinical labs asked us to investigate possible improvements in probe manufacturing on their flagship HPLC instrument.

The Customer Challenge:
During periodic instrument refining, this global customer uncovered a potential problem with the piercing probe at the point of sample aspiration on their HPLC instrument. Although the instrument’s probe functioned as required, coring occurred as it pierced the caps of sample test tubes.

The Solution:
Our engineered solution improved the probe by smoothing the finish to the side-hole port without changing the basic design. As a result, this customer was able to reduce coring by more than 50%, reducing the risk of unwarranted service calls or premature probe replacement.

Have you had experiences in your career where listening to customer needs improved a design and added value? How about where you partnered with a customer to create an innovative solution within design fluidics?

Leave a comment and share your thoughts and experiences.

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